Mar 13, 2023
Tracey returns to the podcast to give an update about his work
at the Feinstein
Institutes and the work at SetPoint Medical.
Top 3 Takeaways:
- "Two years we discovered that a drug called Famotidine, which
is sold as a generic drug Pepcid AC is actually a pharmacological
or a drug-based vagus nerve stimulator. And we proved first in mice
that famotidine placed directly in very small amounts placed
directly in the brains of mice activates the vagus nerve. And this
in turn turned off cytokine storm, which of course is a big problem
in Covid 19"
- "A company that I've co-founded, Setpoint Medical, is currently
deep into clinical trials in the United States called ResetRA,
which is on clinical trials.gov or on the SetPoint website for
rheumatoid arthritis patients. And that trial is enrolling many
patients up to, I think 250 patients will be studied according to
the websites and we're hoping that goes very well. And we're
hoping, I'm hoping that leads to FDA approval for vagus nerve
stimulation in the US in the coming days or coming in the coming
- "I think we're very close now to vagus nerve stimulation
becoming a reality for millions of patients. And I, I hope, and I
see a time when patients have the. Of choosing vagus nerve
stimulation as a simple, safe therapy instead of dangerous,
expensive drugs with black box warnings that are minimally
0;30 "Do you wanna introduce yourself and talk about some of
your work, especially as neuromodulation pertains to the immune
2:45 "So the last time when we talked it was 2020. So pandemic,
everything was upside down. But then you were telling me before we
started recording that it was also especially busy for you at that
time. So what were you up to around then?"
6:00 What were the quantitative takeaways of the Famotidine
8:15 "Why didn't it become standard practice?"
11:00 "You're saying the famotidine has this effect on the vagus
nerve. Does this mean we no longer need vagus nerve
stimulators? Can we just take Pepcid, AC?"
15:00 Do you want to talk about the Bioelectronic Medicine
17:30 What were some of the highlights of the Summit?
19:30 "You mentioned some interesting results. Is that
something you can share now or is that something that we should be
on the lookout for?"
21:30 "You were also featured recently in the Wall Street
Journal and New York Times, what was that like and what were the
23:15 "So what's exciting you now for 2023 and what's on the
horizon for you for the next few years?"
27:15 "Is there anything that we didn't talk about that you
wanted to mention?"